Genome-Wide Mapping of Protein Interactions

The proposed Center for Computational Proteomics Research will develop and validate a broadly accessible software and hardware system for the genome-wide mapping of the protein interactions with small molecules and with other proteins. The Center will consist of six cores: Core 1&2: Genome-Wide Mapping of Protein Interactions Core 3: Driving Biological Projects Core 4: Service to the Biomedical Community Core 5: Training the Center's Graduate and Postdoctoral Students, and the Broader Biomedical Community Core 6: Dissemination of Tools, Data, and Discoveries Core 7: Management and Oversight The broad goal is a comprehensive description of the interactions between biological molecules, which in turn is a prerequisite for the discovery of general structural principles that underlie all cellular processes. Whereas this goal is certainly challenging, its pursuit will have a great impact on biomedical research. Specifically, the Center will (i) dramatically improve access to protein structure modeling and docking, bringing these tools to the general biological community; (ii) allow biologists to develop structural insight into the processes they study; (iii) combine experiment and computation to optimize coverage, accuracy, resolution, efficiency, and cost of biomedical research; (iv) allow the community to begin to address questions that require a comprehensive dataset of protein structures and their interactions; and (v) contribute to drug target discovery, lead discovery, and lead optimization for treatment of human disease.